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10.1056/nejm199906173402418 103 WenzelS

This change is closely related to the increased endogenous estrogen levels during pregnancy, indicating a positive correlation between estrogen and Lactobacillus abundance 26

Early nanoformulations, such as liposomes and polymeric micelles, were primarily designed to improve solubility and pharmacokinetics and to exploit enhanced vascular permeability and impaired lymphatic drainage for passive tumor accumulation [18, 20, 21]